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周焕斌

      

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周焕斌,男,籍贯湖北武汉,中国农业科学院研究员、博士生导师。

2000年和2003年在华中农业大学园艺林学学院分别获蔬菜学学士和硕士学位,2007年在中国科学院遗传与发育生物学研究所获遗传学博士学位。2007至2015年分别在美国加州大学河滨分校植物病理与微生物学系、爱荷华州立大学遗传发育与细胞生物学系从事博士后研究工作。2015年入职俄罗斯284平台。2017年入选中国农科院“青年英才A类”,2019年入选国家高层次人才特殊支持计划青年项目,同年入选中国农科院“农科英才领军人才B类”。目前兼任中国植物病理学会常务理事、副秘书长;中国作物学会分子育种分会理事;中国生物工程学会生物农业分会理事;BMC Plant Biology和Frontiers in Genome Editing杂志Associate editor、生物技术通报编委。

研究组承担国家自然科学基金、中挪国际合作、国家重点研发计划专项、国家转基因重大专项等项目多项。主要从事基因组编辑技术开发和植保应用,涉及1)病原微生物基因组编辑技术开发,借助其阐述病原菌致病机理以及创制高活性工程菌株;2)植物基因组编辑技术开发和作物分子精准育种新方法研究,借助其发掘抗病、耐除草剂等重要功能基因资源,培育基因组编辑抗性水稻新材料和新品种,为实现我国农业绿色植:褪迪治夜┮悼沙中⒄固峁┲匾С。目前已获得国家发明授权专利7项,在Cell Host & Microbe, Nucleic Acids Res, Genome Biol, Mol Plant, Plant Biotech J, Plant Physiol, Plant J等国内外重要学术期刊上发表论文30多篇,其中8篇为ESI高被引论文,总引用率达2200多次。

联系方式:zhouhuanbin@caas.cn

个人网址:https://www.researchgate.net/profile/Huanbin_Zhou

代表性论文(#通讯作者)

1. S Li#, C Wang, C You, X Zhou & H Zhou#. T-LOC: A comprehensive tool to localize and characterize the T-DNA integration sites.  Plant Physiology.  2022, https://doi.org/10.1093/plphys/kiac225.

2. S Li#, L Liu, W Sun, X Zhou & H Zhou#. A large-scale genome and transcriptome sequencing analysis reveals the mutation landscapes induced by high-activity adenine base editors in plants.  Genome Biol . 2022, 23: 51.

3. K Wang*, H Zhou*& Q Qian#. The rice codebook: from reading to editing. Mol. Plant . 2022, 15: 569-572.

4. G Gosavi, B Ren, X Li, X Zhou, C Spetz# & H Zhou#. The new era of creating herbicide-tolerant crops through genome editing.  ACS Agr Sci. & Technol . 2022, 2: 184-191.

5. G Ma, Y Kuang, Z Lu, X Li, Z Xu, B Ren, X Zhou & H Zhou#. CRISPR/Sc++ system-mediated genome modification in rice.  J Integr Plant Biol . 2021, 63: 1606-610.

6. H Zhou#, Y Zhang, L Xia & S Toki. Editorial: Targeted genome editing in crops.  Front. Genome Ed. 2021, 3: 757916.

7. C Yang, R Liu, J Pang, B Ren, H Zhou, G Wang, E Wang & Jun Liu#. Poaceae-specific, cell wall-derived oligosaccharides activate plant immunity via  OsCERK1 during  Magnaporthe oryzae infection in rice.  Nat. Commun.  2021, 12: 2178.

8. D Yan, B Ren, L Liu, F Yan, S Li, G Wang, W Sun, X Zhou & H Zhou#. High-efficiency and multiplex adenine base editing in plants using new TadA variants.  Mol. Plant. 2021, 14(5): 722-731. (ESI高被引论文)

9. Z Xu, Y Kuang, B Ren, D Yan, F Yan, C Spetz, W Sun, G Wang, X Zhou# & H Zhou#. SpRY greatly expands the genome editing scope in rice with highly flexible PAM recognition.  Genome Biol.  2021, 22: 6. (ESI高被引论文)

10. L Liu, Y Kuang, F Yan, S Li, B Ren, G Gosavi, C Spetz, X Li, X Wang, X Zhou & H Zhou#. Developing a novel artificial rice germplasm for dinitroaniline herbicide resistance by base editing of  OsTubA2 .  Plant Biotech. J.  2021, 19(1): 5-7.

11. Y Cao, H Zhou, X Zhou#, F Li#. Control of plant viruses by CRISPR/Cas system-mediated adaptive immunity.  Front. Microbiol. 2020, 11: 593700.

12. G Gosavi, F Yan, B Ren, Y Kuang, D Yan, X Zhou & H Zhou#. Applications of CRISPR technology in studying plant-pathogen interactions: overview and perspective.  Phytopathol. Res. 2020, 2: 21.

13. M Wang, Z Xu, G Gosavi, B Ren, Y Cao, Y Kuang, C Zhou, C Spetz, F Yan, X Zhou & H Zhou#. Targeted base editing in rice with CRISPR/ScCas9 system.  Plant Biotech. J. 2020, 18(8): 1645-1647.

14. Y Kuang, S Li, B Ren, F Yan, C Spetz, X Li, X Zhou & H Zhou#. Base-editing-mediated artificial evolution of  OsALS1 in planta to develop novel herbicide-tolerant rice germplasms.  Mol. Plant  2020, 13(4): 565-572. (ESI高被引论文)

15. X Yang, H Zhou and X Zhou#. Rock paper scissors: CRISPR/Cas9-mediated interference with geminiviruses in plants.  Sci. China. Life Sci.  2019, 62(10): 1389-1391.

16. B Ren, L Liu, S Li, Y Kuang, J Wang, D Zhang, X Zhou, H Lin# & H Zhou#. Cas9-NG greatly expands the targeting scope of the genome-editing toolkit by recognizing NG and other atypical PAMs in rice.  Mol. Plant  2019, 12(7): 1015-1026. (ESI高被引论文)

17. J. Long, C. Song, F. Yan, J. Zhou, H. Zhou# & B. Yang#. Non-TAL effectors from  Xanthomonas oryzae pv.  oryzae suppress peptidoglycan-triggered MAPK activation in rice.  Front. Plant Sci.  2018, 9: 1857.

18. F. Yan, Y. Kuang, B. Ren, J Wang, D. Zhang, H. Lin, B. Yang, X. Zhou & H. Zhou#. Highly efficient A·T to G·C base editing by Cas9n-guided tRNA adenosine deaminase in rice.  Mol. Plant  2018, 11(4): 631-634. (ESI高被引论文)

19. B. Ren, F. Yan, Y. Kuang, N. Li, D. Zhang, X. Zhou, H. Lin# & H. Zhou#. Improved base editor for efficiently inducing genetic variations in rice with CRISPR/Cas9-guided hyperactive hAID mutant.  Mol. Plant 2018, 11(4): 623-626. (ESI高被引论文)

20. B. Ren, F. Yan, Y. Kuang, N. Li, D. Zhang, H. Lin# & H. Zhou#. A CRISPR/Cas9 toolkit for efficient targeted base editing to induce genetic variations in rice.  Sci. China. Life Sci.  2017, 60(5): 516-519. (第二届中国科协优秀科技论文遴选计划入选论文)



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